Gross murine leukemia virus-induced alterations in the thymus of preleukemic AKR mice.
نویسندگان
چکیده
AKA mice were inoculated with Gross mumine leukemia virus at 3 days of age. Such treatment results in thymic lymphoma in all animals between 8 and 12 weeks of age. Normal AKA mice develop the disease after 28 weeks of age. In this study, virus-treated (AKA-V) and normal (AKR N) mice were compared. Thymic weights, histology, and cell density as well as functional and mitogen assays of thymocytes and peripheral T-cebls were studied. These animals were studied in the fifth week of life, a time of peak thymic size, and when the virus-inoculated mice were not yet leukemic but were a few weeks away from development
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عنوان ژورنال:
- Cancer research
دوره 39 2 Pt 1 شماره
صفحات -
تاریخ انتشار 1979